Table 1.
Patient characteristics
| Variables | Cohort A N=45 (%)# |
Cohort B N=43 (%) |
p- value |
|
|---|---|---|---|---|
| Age * | Median | 64.0 (57.0 – 68.0) | 61.0 (56.5 – 68.5) | 0.70 |
| Gender | Male | 37 (82) | 28 (65) | 0.11 |
| Female | 8 (18) | 15 (35) | ||
| Race | White | 40 (89) | 37 (86) | 0.89 |
| Black | 3 (7) | 3 (7) | ||
| Other | 2 (4) | 3 (7) | ||
| ECOG | 0 | 9 (20) | 19 (44) | 0.03 |
| 1 | 33 (73) | 20 (47) | ||
| 2 | 3 (7) | 4 (9) | ||
| Smoking History | Yes | 33 (73) | 27 (63) | 0.41 |
| No | 12 (27) | 16 (37) | ||
| Primary Site | Oral Cavity | 10 (22) | 17 (40) | 0.53 |
| Oropharynx (OP) | 24 (53) | 17 (40) | ||
| Larynx | 6 (13) | 6 (14) | ||
| Hypopharynx | 3 (7) | 2 (5) | ||
| Unknown Primary (UP) | 2 (4) | 1 (2) | ||
| p16 IHC | OP+UP pos | 22 (49) | 14 (33) | 0.14 |
| OP neg | 4 (9) | 4 (9) | ||
| Non-OP pos | 0 (0) | 4 (9) | ||
| Non-OP neg | 19 (42) | 21 (49) | ||
| PD-L1 CPS | <1 | 7 (16) | 7 (16) | 0.84 |
| 1-19 | 13 (29) | 13 (30) | ||
| ≥20 | 19 (42) | 20 (47) | ||
| NA | 6 (13) | 3 (7) | ||
| Line of prior therapy for R/M HNSCC | 0 | 11 (24) | 43 (100) | N/A |
| 1 | 27 (60) | 0 | ||
| 2 | 5 (11) | 0 | ||
| 3 | 2 (4) | 0 |
*
Median and inter-quartile range is given for age
#
Reference (21)
N/A – not applicable
R/M HNSCC – recurrent and/or metastatic head and neck squamous cell carcinoma