Table 2.
Summary of Grade 3 or 4 Toxicities in Cohort B (N=43)
| TREATMENT-RELATED TOXICITIES | GRADE 3 | GRADE 4 | TOTAL |
|---|---|---|---|
| Rash acneiform* | 4 (9) | - | 4 (9) |
| Hypomagnesemia | 1 (2) | 1 (2) | 2 (5) |
| Paronychia* | 1 (2) | - | 1 (2) |
| Fatigue | 1 (2) | - | 1 (2) |
| Diarrhea | 1 (2) | - | 1 (2) |
| Hypophosphatemia | 2 (5) | - | 2(5) |
| Hypokalemia | 1 (2) | - | 1 (2) |
| Lymphocyte count decreased | 1 (2) | - | 1 (2)) |
| Rash maculo-papular* | 1 (2) | - | 1 (2) |
| Nausea | 1 (2) | - | 1 (2) |
| Alanine aminotransferase increased | 1 (2) | - | 1 (2) |
| Aspartate aminotransferase increased | 1 (2) | - | 1 (2) |
| Colitis | 1 (2) | - | 1 (2) |
| Musculoskeletal and connective tissue disorder - Other, specify | 1 (2) | - | 2 (5) |
| Vascular disorders - Other, specify | 1 (2) | - | 1 (2) |
| Overall | 9 (21) | 1 (2) | 42 (98) |
| IMMUNE-RELATED TOXICITIES | GRADE 3 | GRADE 4 | TOTAL |
| Fatigue | 2 (5) | - | 2 (5) |
| Alanine aminotransferase increased | 1 (2) | - | 1 (2) |
| Hypophosphatemia | 1 (2) | - | 1 (2) |
| Aspartate aminotransferase increased | 1 (2) | - | 1 (2) |
| Rash maculo-papular* | 1 (2) | - | 1 (2) |
| Vascular disorders - Other, specify | 1 (2) | - | 1 (2) |
| Overall | 4 (9) | 0 (0.0) | 15 (35) |
*
Skin and nail-related toxicities