Table 2.

Relative Risk Ratios (RRR) for prevention-effective adherence trajectory among transgender women indicated for and/or using PrEP in the LITE cohort (N=540)

	Unadjusted Relative Risk Ratios				Adjusted Relative Risk Ratios
Reference Group: Group 4: Consistent indication/PrEP adherent	RRR	P-value	95% CI		aRRR	P-value	95% CI
Group 1: Consistent indication/no PrEP
Youth (Aged 18–24)	1.18	0.67	0.56	2.5	1.18	0.69	0.52	2.66
Black	0.98	0.95	0.53	1.81	0.62	0.25	0.28	1.40
Latina	0.78	0.44	0.41	1.48	0.47	0.06	0.21	1.04
Census division (ref=New England)
Mid-Atlantic	0.80	0.66	0.30	2.12	0.92	0.88	0.31	2.69
South Atlantic	0.97	0.94	0.40	2.36	1.02	0.96	0.37	2.86
College education or higher (ref=high school diploma/GED or less)	0.57	0.08	0.30	1.07	0.63	0.22	0.30	1.31
Homelessness¶	1.69	0.16	0.82	3.51	2.07	0.09	0.88	4.82
Arrest¶	2.81	0.07	0.92	8.59	2.56	0.16	0.69	9.52
Uninsured¶	2.52	0.05	1.00	6.32	1.47	0.48	0.51	4.24
Lab-confirmed STI¶	2.37	0.01	1.22	4.61	2.54	0.02	1.16	5.57
1 or more current partner using PrEP¶	0.25	<0.001	0.13	0.47	0.18	<0.001	0.09	0.36
6+ months since last healthcare encounter	4.90	<0.01	1.53	15.71	5.66	0.02	1.40	22.85
Anticipated discrimination in healthcare	0.90	0.73	0.49	1.64	1.02	0.95	0.50	2.07
Group 2: Initial indication/no PrEP
Youth (Aged 18–24)	2.90	<0.001	1.64	5.11	3.04	<0.001	1.60	5.78
Black	0.78	0.32	0.49	1.26	0.62	0.14	0.33	1.17
Latina	0.80	0.38	0.49	1.31	0.71	0.27	0.39	1.30
Census division (ref=New England)
Mid-Atlantic	0.66	0.26	0.32	1.36	0.73	0.45	0.32	1.67
South Atlantic	0.52	0.06	0.26	1.04	0.8	0.58	0.36	1.78
College education or higher (ref=high school diploma/GED or less)	0.69	0.16	0.42	1.15	0.9	0.75	0.49	1.67
Homelessness¶	1.66	0.09	0.92	2.99	1.87	0.10	0.89	3.94
Arrest¶	1.31	0.61	0.47	3.65	1.03	0.97	0.28	3.81
Uninsured¶	1.50	0.33	0.66	3.4	1.52	0.38	0.59	3.91
Lab-confirmed STI¶	0.43	<0.01	0.23	0.8	0.45	0.03	0.21	0.94
1 or more current partner using PrEP¶	0.19	<0.001	0.12	0.31	0.15	<0.001	0.09	0.27
6+ months since last healthcare encounter	1.88	0.26	0.62	5.67	2.1	0.29	0.54	8.21
Anticipated discrimination in healthcare	0.89	0.64	0.56	1.43	0.83	0.51	0.46	1.47
Group 3: Declining indication/discontinued PrEP
Youth (Aged 18–24)	2.00	0.08	0.92	4.36	1.48	0.38	0.62	3.56
Black	1.26	0.50	0.64	2.50	0.81	0.63	0.34	1.93
Latina	1.06	0.87	0.52	2.16	0.82	0.64	0.36	1.88
Census division (ref=New England)
Mid-Atlantic	1.15	0.79	0.41	3.25	1.32	0.64	0.41	4.23
South Atlantic	0.65	0.40	0.24	1.78	0.88	0.83	0.28	2.80
College education or higher (ref=high school diploma/GED or less)	0.26	<0.001	0.13	0.53	0.28	<0.01	0.13	0.63
Homelessness¶	2.78	<0.01	1.29	5.99	2.71	0.03	1.10	6.70
Arrest¶	0.78	0.78	0.15	4.19	0.91	0.92	0.15	5.62
Uninsured¶	0.87	0.83	0.25	3.05	0.76	0.69	0.20	2.93
Lab-confirmed STI¶	1.11	0.79	0.5	2.49	1.03	0.95	0.41	2.60
1 or more current partner using PrEP¶	0.65	0.21	0.33	1.28	0.59	0.18	0.28	1.27
6+ months since last healthcare encounter	0.95	0.95	0.17	5.37	1.79	0.54	0.27	11.8
Anticipated discrimination in healthcare	0.94	0.87	0.47	1.88	1.01	0.98	0.46	2.23
Group 5: Increasing indication/initiated PrEP
Youth (Aged 18–24 at enrollment)	2.61	0.02	1.21	5.66	2.15	0.09	0.90	5.15
Black	1.90	0.07	0.94	3.84	1.5	0.37	0.62	3.66
Latina	0.75	0.46	0.36	1.59	0.64	0.33	0.26	1.56
Census division (ref=New England)
Mid-Atlantic	0.73	0.58	0.25	2.17	0.81	0.74	0.24	2.80
South Atlantic	0.80	0.66	0.3	2.16	0.88	0.84	0.27	2.91
College education or higher (ref=high school diploma/GED or less)	0.44	0.03	0.22	0.9	0.65	0.31	0.28	1.49
Homelessness¶	2.56	0.02	1.17	5.63	2.83	0.03	1.13	7.05
Arrest¶	2.62	0.13	0.76	9.07	1.99	0.38	0.43	9.17
Uninsured¶	1.54	0.45	0.5	4.73	1.25	0.72	0.36	4.32
Lab-confirmed STI¶	1.20	0.65	0.54	2.71	0.71	0.49	0.27	1.87
1 or more current partner using PrEP¶	0.76	0.45	0.38	1.53	0.78	0.53	0.35	1.72
6+ months since last healthcare encounter	2.70	0.15	0.69	10.54	3.44	0.14	0.67	17.52
Anticipated discrimination in healthcare	0.50	0.07	0.23	1.06	0.51	0.13	0.21	1.23

^¶At any point over follow-up. All other indicators were assessed at baseline only.