Table 6.
Treatment-related adverse events of triple therapy.
| Events | All grade | Grade≥3 | ||||||
|---|---|---|---|---|---|---|---|---|
| Included studies | Participants | Effect model | Proportion (95CI) | Included studies | Participants | Effect model | Proportion (95CI) | |
| Elevated ALT | 9 | 439 | Random | 0.436 (0.326-0.550) | 9 | 425 | Random | 0.048 (0.013-0.101) |
| Elevated AST | 8 | 355 | Random | 0.427 (0.309-0.548) | 9 | 425 | Random | 0.052 (0.013-0.109) |
| Elevated TBil | 11 | 513 | Random | 0.274 (0.171-0.389) | 10 | 429 | Fixed | 0.021 (0.007-0.040) |
| Thrombocytopenia | 7 | 351 | Random | 0.183 (0.069-0.331) | 7 | 337 | Fixed | 0.039 (0.018-0.064) |
| Decreased appetite | 10 | 495 | Random | 0.198 (0.123-0.285) | 10 | 481 | Fixed | 0.007 (0.000-0.025) |
| Fatigue | 10 | 513 | Random | 0.231 (0.141-0.334) | 10 | 499 | Random | 0.013 (0.001-0.034) |
| Hypertension | 12 | 604 | Random | 0.295 (0.246-0.346) | 12 | 590 | Random | 0.061 (0.027-0.105) |
| Abdominal pain | 9 | 460 | Random | 0.243 (0.165-0.330) | 8 | 376 | Fixed | 0.015 (0.003-0.034) |
| Diarrhea | 12 | 593 | Random | 0.160 (0.117-0.207) | 12 | 579 | Fixed | 0.017 (0.006-0.032) |
| Proteinuria | 11 | 520 | Random | 0.204 (0.142-0.274) | 11 | 520 | Fixed | 0.016 (0.005-0.032) |
| Hand–foot syndrome | 10 | 495 | Random | 0.232 (0.162-0.309) | 10 | 495 | Fixed | 0.029 (0.012-0.051) |
| Rash | 10 | 503 | Fixed | 0.115 (0.087-0.145) | 11 | 511 | Random | 0.013 (0.000-0.047) |
| Hypothyroidism | 11 | 565 | Random | 0.165 (0.090-0.256) | 12 | 573 | Fixed | 0.004 (0.000-0.015) |
| Fever | 6 | 273 | Random | 0.312 (0.185-0.455) | 6 | 259 | Fixed | 0.014 (0.000-0.038) |
| Nausea and vomiting | 9 | 432 | Random | 0.157 (0.086-0.243) | 9 | 418 | Random | 0.022 (0.001-0.060) |
| Arthralgia | 4 | 119 | Fixed | 0.085 (0.038-0.146) | 5 | 189 | Fixed | 0.004 (0.000-0.025) |
| Hoarseness | 4 | 174 | Fixed | 0.060 (0.026-0.103) | 4 | 174 | Fixed | 0.000 (0.000-0.016) |
| GI bleeding | 4 | 213 | Fixed | 0.039 (0.014-0.072) | 4 | 213 | Random | 0.008 (0.000-0.043) |
| RCCEP | 4 | 194 | Random | 0.226 (0.103-0.379) | 3 | 114 | – | 0.000 |
| Mouth ulcers | 3 | 158 | Fixed | 0.054 (0.021-0.098) | 3 | 158 | – | 0.000 |
ALT, alanine aminotransferase; AST, aspartate aminotransferase; GI, gastrointestinal tract; RCCEP, reactive cutaneous capillary endothelial proliferation.