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. 2022 May 23;10:840171. doi: 10.3389/fcell.2022.840171

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Copyright © 2022 Wu, Rong, Pan, Wang, Yang, Chen, Xiao and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptomic alterations in TMAO-induced primary liver cancer cells. (A) Venn diagrams showing the crossover between the differentially expressed genes (DEGs) in untreated Hepa1-6 cells (Group Ctrl), and Hepa1-6 cells treated with 50 μM TMAO alone (Group 50T), 50 ng/ml TNF-α alone (Group 50α) or 50 ng/ml TNF-α and 50 μM TMAO in combination (Group 50T + 50α). (B) Heatmap showing the DEGs common to the four treatment groups; FC > 2 and p < 0.05. (C) Heatmap showing the DEGs common to Group 50α and Group 50T + 50α; FC > 2 and p < 0.05. (D) Volcano map showing the significant differentially expressed genes between Group 50α and Group 50T + 50α; FC > 2 and p < 0.05; FC: Fold change.