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. 2022 May 23;9:856749. doi: 10.3389/fcvm.2022.856749

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Copyright © 2022 Chen, Liu, Deng, Yang, Wang, Lin, Yu, Pu, Zhang, Li, Zhong, Jia, Li, Wang, Chen, Burkhoff and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Typical changes of cardiac morphology during various durations of exposure to high altitude. End-systolic short-axis images. (A) Han lowlanders (controls) with normal volume and thickness. (B) Short-term Hans migrants (<1 year) had enlarged RV with the leftward shifted interventricular septum. (C) Long-term Hans migrants (>5 years) had significantly thickened LV wall with recovered RV size. (D) Native Tibetans had no or minimal differences in LV structure compared with Han lowlanders. RV, right ventricular; LV, left ventricular.