Figure 7.

Strain-specific response signatures to obesogenic diet

Radar plots of some hallmarks reflecting predisposition to metabolic disease in each strain. Each parameter is expressed as a percentage of the highest strain. Fibrogenesis and inflammation scores are based on the normalized enrichment score of the GSEA for “collagen-containing extracellular matrix” and “humoral immune response,” respectively. Insulin resistance is based on Homa-IR value under HFD. Obesity is based on body weight gain relative to the starting weight before HFD. Finally, glucose clearance loss is the change in the slope of glucose clearance in the OGTT test upon HFD (missing data in the NZO strain, due to a too severe phenotype).