REAGENT or RESOURCE	SOURCE	IDENTIFIER
Chemicals, peptides, and recombinant proteins
TRIzol	Invitrogen	Cat#15596026
Direct-zol-96 RNA kits	Zymo	Cat# R2056
Critical commercial assays
Metabolic Modular Treadmill	Columbus Instruments	N/A
Metabolic cages	TSE systems	N/A
Oxymax/CLAMS	Columbus Instruments	N/A
Echo-MRI 3-in-1	Echo Medical Systems	N/A
Mitochondrial function assay	IntegraCell	N/A
Deposited data
RNAseq	Gene Expression Omnibus	GEO: GSE182668
Metabolic traits	Mouse Phenome Database	MPD: Auwerx2 identifier
Experimental models: Organisms/strains
C57BL6/J	Jackson Laboratory	RRID:IMSR_JAX:000664
DBA2/J	Jackson Laboratory	RRID:IMSR_JAX:000671
A/J	Jackson Laboratory	RRID:IMSR_JAX:000646
129S1/SvlmJ	Jackson Laboratory	RRID:IMSR_JAX:002448
NOD/ShiLtJ	Jackson Laboratory	RRID:IMSR_JAX:001976
NZO/HILtJ	Jackson Laboratory	RRID:IMSR_JAX:002105
WSB/EiJ	Jackson Laboratory	RRID:IMSR_JAX:001145
CAST/EiJ	Jackson Laboratory	RRID:IMSR_JAX:000928
PWK/PhJ	Jackson Laboratory	RRID:IMSR_JAX:003715
Software and algorithms
R software version 3.5.2	R project	https://www.r-project.org/
Rstudio Pro version 1.4.1717-3	Rstudio	https://www.rstudio.com/
variantPartition version: 1.12.3	Bioconductor	http://bioconductor.org/packages/release/bioc/html/variancePartition.html
limma version 3.38.3	Bioconductor	https://bioconductor.org/packages/release/bioc/html/limma.html
data.table version 1.13.0	CRAN	https://cran.r-project.org/web/packages/data.table/
clusterprofiler version 3.10.1	Bioconductor	https://bioconductor.org/packages/release/bioc/html/clusterProfiler.html
ggplot2 version 2 2.0.0	CRAN	https://cran.r-project.org/web/packages/ggplot2/index.html
cowplot version 1.1.1	Github	https://github.com/wilkelab/cowplot
Other
Interactive application	Systems-genetics.org	www.systems-genetics.org/CC_founders_metabolic