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. 2022 May 23;13:864674. doi: 10.3389/fimmu.2022.864674

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Copyright © 2022 Versteegen, Barkoff, Valente Pinto, van de Kasteele, Knuutila, Bibi, de Rond, Teräsjärvi, Sanders, de Zeeuw-Brouwer, Luoto, ten Hulscher, Clutterbuck, Sanders, Mertsola, Berbers, He, Kelly, Buisman and PERISCOPE Consortium

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Geometric mean memory B cell frequencies per priming vaccination background with 95% confidence intervals. Significances were calculated using a linear mixed model on the log10 transformed data taking the longitudinal structure into account. Bmems, memory B cell frequencies; PBMCs, peripheral blood mononuclear cells. Memory B cell frequencies in adolescents from the Netherlands and Finland together (aP priming n=22, wP priming n=18) specific for (A) pertussis toxin; (B) filamentous haemagglutinin; and (C) pertactin. Observed differences between the aP and wP primed cohorts did not reach significance.