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. 2022 Apr 29;298(6):101999. doi: 10.1016/j.jbc.2022.101999

Figure 2.

Figure 2

Nerve injury increases CB2 expression in DRG neurons.A, representative low- and high-magnification images of RNAscope in situ hybridization show colabeling of NeuN (green) and CB2 mRNA (red) in DRG tissue sections from sham and SNL rats 10 days after surgery. B–D, quantification of CB2 mRNA punctate signals in the DRG tissue section (B), the abundance of CB2 mRNA signals in DRG neurons (C), and amount of CB2 mRNA signals in small-, medium-, and large-diameter DRG neurons (D) in sham and SNL rats. Data are shown as means ± SEM (n = 9 images per group). ∗p < 0.05, ∗∗∗p < 0.001 compared with the sham group (Two-tailed Student’s t test). CB2, Type-2 cannabinoid receptors; DRG, dorsal root ganglion; SNL, spinal nerve ligation.