Figure 4.

Evaluation of the CTCR model in TCGA-LUAD cohort (n = 447). (a) Survival status and risk scores in the training cohort. (b) PCA analysis of grouped samples in the training cohort. (c) KM curves demonstrating longer OS in the low-risk group. (d) AUC values of time-dependent ROC curves verify the predictive accuracy of the risk score. (E, F) Univariate and multivariate Cox analyses were performed to examine the correlation among clinical features, risk scores and OS. (G) Comparison of ROC curves among patients with different clinical characteristics, such as age, sex and stage, and risk scores in the training cohort. (H) Nomogram based on the 4 CTC-related genes quantitatively predicts the survival of patients with LUAD. (i) Calibration plot for internal validation of the nomogram.