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. 2022 May 23;12:859721. doi: 10.3389/fonc.2022.859721

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Copyright © 2022 Zhong, Wei, Liao, Wang, Peng, Zhou, Huang, Xian, Peng, Zhang, Feng, Liu, Hong, Xia, Yan, Liu and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential genera serving as prognostic factors for NPC. (A) The alpha diversity in the NR and R groups is estimated by Shannon index. (B) Significant genera in relative abundance detected by a MaAsLin model with adjustment for age * means (corrected Q value < 0.25). (C) ROC curve analysis of differential genera for diagnosis of R from NR for NPC treatments. (D) Forest plot reveals the selected covariates on clinical characteristics and significant genera tested by multivariate COX regression analysis. (E) Kaplan-Meier (K-M) plot of the PFS by Log-rank test in patients with high relative abundance and low relative abundance of Turicibacter (cutoff: 0.0046).