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Targeting autophagy in stem cells. Inhibiting autophagy in cancer stem cells could be considered a valid strategy to eliminate tumor-initiating cells and prevent cancer treatment resistance. In contrast, induction of autophagy could improve stem cell transplantation therapies and aged stem cell function, facilitate the conversion of somatic cells into the tissue-specific stem cells and promote reprogramming of somatic cells into the induced pluripotent stem cells (iPSC).
