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Enzyme inhibitory and antiproliferative activities of the derived APN inhibitors. a: APN enzyme inhibitory rates (A) of the synthesized compounds; (B) IC50 values of selected compounds; (C) antiproliferative activities of representative compounds in combination with chemotherapeutic drugs against MDA-MB-231 cells; (D) antiproliferative activities of representative compounds in combination with chemotherapeutic drugs against MDA-MB-468 cells; *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001.
