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. 2022 May 23;12:894842. doi: 10.3389/fonc.2022.894842

Figure 4.

Figure 4

Effects of PTX-APN inhibitor combinations on spheroid and colony formation of tested TNBC cells, and on mRNA expression levels of OCT-4, SOX-2 and Nanog in the tested TNBC stem cells. (A) MDA-MB-231 cell spheroid formation affected by different PTX-APN inhibitor combinations; (B) MDA-MB-468 cell spheroid formation affected by different PTX-APN inhibitor combinations; (C) MDA-MB-231 cell colony formation affected by different PTX-APN inhibitor combinations; (D) MDA-MB-468 cell colony formation affected by different PTX-APN inhibitor combinations; (E) regulation of mRNA expression levels of OCT-4, SOX-2 and Nanog by different PTX-APN inhibitor combinations in MDA-MB-231 cells; (F) regulation of mRNA expression levels of OCT-4, SOX-2 and Nanog by different PTX-APN inhibitor combinations in MDA-MB-468 cells; *P ≤ 0.05, **P ≤ 0.01.