Fig. 1.

Schematic of intratumoral drug concentration as a function of time for MTD, metronomic chemotherapy and nanomedicine based on model simulations. MTD treatment causes increased peak concentration of the drug to the tumor but the less frequent dose schedule results in longer drug free periods. Metronomic scheduling of chemotherapy and nanomedicines ensure effective drug levels in the blood for longer periods. Concentration values are normalized to that of MTD. Dose schedule was based on our previous work [41].