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. 2022 May 23;12:900203. doi: 10.3389/fonc.2022.900203

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Copyright © 2022 Xin, Deng, Mao, Wang, Liu, Wang, Song, Song and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association between the TIME and m7G model. (A) The ESTIMATE of tumor microenvironment in the two m7Gscore-defined groups. (B) MHC, costimulatory, and adhesion molecule expression in the m7Gscore-defined groups. (C, D) Enrichment indices of TIICs (C) and immune functions (D) in the m7Gscore-defined groups with ssGSEA. (E) Evaluation of the correlation between m7Gscore and the infiltration level of TIICs with comprehensive algorithms. TIME, tumor immune microenvironment; m7G, 7-methylguanosine; MHC, major histocompatibility complex; TIICs, tumor-infiltrating immune cells; ssGSEA, single-sample gene set enrichment analysis. *p < 0.05; **p < 0.01; ***p < 0.001. ns, no significance.