Table 1.
Comparison of Baseline Demographic, Laboratory, and Clinicopathological Parameters between AFP Groups.
| Parameter | AFP<10 n = 92 | AFP 10–400 n = 146 | AFP>400 n = 270 | P value | Pairwise comparisons P value |
||
|---|---|---|---|---|---|---|---|
| (a) vs (b) | (a) vs (c) | (b) vs (c) | |||||
| Age | 57.9 ± 13.5 | 58.3 ± 11.9 | 53.7 ± 12.6 | <0.0011 | 0.5712 | 0.0252 | <0.0012 |
| Gender | 0.7023 | ||||||
| Male | 82 (89.1%) | 125 (85.6%) | 237 (87.8%) | >0.054 | >0.054 | >0.054 | |
| Female | 10 (10.9%) | 21 (14.4%) | 33 (12.2%) | >0.054 | >0.054 | >0.054 | |
| Etiology | 0.1293 | ||||||
| HBHC | 49 (53.3%) | 85 (58.2%) | 174 (64.4%) | >0.054 | >0.054 | >0.054 | |
| NBNC | 43 (46.7%) | 61 (41.8%) | 96 (35.6%) | >0.054 | >0.054 | >0.054 | |
| Bilirubin | 1.7 ± 2.2 | 1.8 ± 1.4 | 2.3 ± 3.0 | <0.0011 | 0.0062 | <0.0012 | 0.4102 |
| Albumin | 3.6 ± 0.6 | 3.4 ± 0.6 | 3.4 ± 0.6 | 0.0241 | 0.0232 | 0.0752 | 0.4092 |
| AST | 82.7 ± 139.6 | 105.2 ± 78.7 | 155.7 ± 145.5 | <0.0011 | <0.0012 | <0.0012 | 0.0022 |
| ALT | 53.1 ± 54.2 | 67.7 ± 50.3 | 70.8 ± 53.8 | <0.0011 | <0.0012 | <0.0012 | 0.3942 |
| INR | 1.13 ± 0.22 | 1.17 ± 0.22 | 1.22 ± 0.31 | 0.0181 | 0.4592 | 0.0162 | 0.4752 |
| Extrahepatic metastasis (yes) | 13 (14.1%) | 27 (18.5%) | 69 (25.6%) | 0.0413 | >0.054 | >0.054 | >0.054 |
| PVTT (yes) | 21 (22.8%) | 56 (38.4%) | 157 (58.1%) | <0.0013 | <0.054 | <0.054 | <0.054 |
| MTD (cm) | 7.6 ± 3.5 | 8.3 ± 3.6 | 9.1 ± 3.4 | <0.0011 | 0.3392 | 0.0012 | 0.052 |
| BCLC stage | <0.0013 | ||||||
| 0 | 0 | 2 (1.4%) | 1 (0.4%) | >0.054 | >0.054 | >0.054 | |
| A | 16 (17.4%) | 11 (7.5%) | 5 (1.9%) | >0.054 | <0.054 | <0.054 | |
| B | 41 (44.6%) | 58 (39.7%) | 63 (23.3%) | >0.054 | <0.054 | <0.054 | |
| C | 25 (27.2%) | 58 (39.7%) | 149 (55.2%) | >0.054 | <0.054 | <0.054 | |
| D | 10 (10.9%) | 17 (11.6%) | 52 (19.3%) | >0.054 | >0.054 | >0.054 | |
| Child Pugh stage | 0.0383 | ||||||
| A | 41 (44.6%) | 60 (41.1%) | 98 (36.3%) | >0.054 | >0.054 | >0.054 | |
| B | 17 (18.5%) | 50 (34.2%) | 75 (27.8%) | <0.054 | >0.054 | >0.054 | |
| C | 8 (8.7%) | 12 (8.2%) | 37 (13.7%) | >0.054 | >0.054 | >0.054 | |
| Noncirrhotic | 26 (28.3%) | 24 (16.4%) | 60 (22.2%) | >0.054 | >0.054 | >0.054 | |
| Bilobar disease | 38 (41.3%) | 60 (41.1%) | 136 (50.4%) | 0.1163 | >0.054 | >0.054 | >0.054 |
| Pathological grade (n=138) | <0.0413 | ||||||
| Well | 17 (44.7%) | 9 (22%) | 8 (13.6%) | <0.054 | <0.054 | >0.054 | |
| Moderate | 14 (36.8%) | 20 (48.8%) | 30 (50.8%) | >0.054 | >0.054 | >0.05 | |
| Poor | 6 (15.8%) | 10 (24.4%) | 19 (32.2%) | >0.054 | >0.054 | >0.054 | |
| Undifferentiated | 1 (2.6%) | 2 (4.9%) | 2 (3.4%) | >0.054 | >0.054 | >0.054 | |
| MTD (cm) | <0.0053 | ||||||
| <3 | 10 (10.9%) | 10 (6.8%) | 10 (3.1%) | >0.054 | <0.054 | >0.054 | |
| 3–5 | 16 (17.4%) | 20 (13.7%) | 22 (8.1%) | >0.054 | <0.054 | >0.054 | |
| >5 | 66 (71.7%) | 116 (79.5%) | 238 (88.1%) | >0.054 | <0.054 | >0.054 | |
All values: Means ± Standard Deviation as continuous; Frequencies and percentage (%) as categorical. AFP (ng/ml), Albumin (G/dl), AST/ALT (iu/L), Bilirubin (mg/dl), MTD (cm).
1. Kruskal–Wallis test 2. Dunn posthoc method 3. Chi-square 4. z test to compare column proportions with adjusted P values (Bonferroni method).