Table 5.
Univariate and Multivariable Logistic Regression Analysis of the Association of AFP Levels With Barcelona Clinic Liver Cancer (BCLC) Stage.
| Variable | BCLC stage |
P value | OR (95% CI) (univariate) | OR (95% CI, P value) (multivariate) | |
|---|---|---|---|---|---|
| 0/A/B n = 197 | C/D n = 311 | ||||
| Gender | 0.381 | ||||
| Male | 169 (85.8%) | 275 (88.4%) | 1.27 (0.74–2.15) | ||
| Female | 28 (14.2%) | 36 (11.6%) | Ref | ||
| Age | 0.191 | ||||
| ≤40 | 24 (12.2%) | 51 (16.4%) | 1.41 (0.84–2.38) | ||
| >40 | 173 (87.8%) | 260 (83.6%) | Ref | ||
| Etiology | 0.1661 | ||||
| HBHC | 112 (56.8%) | 196 (63%) | 1.29 (0.89–1.86) | ||
| NBNC | 85 (43.2%) | 115 (37%) | Ref | ||
|
AFP (ng/ml) (mean ± SD) |
19253.82 ± 75818.01 | 99813.94 ± 279898.01 | <0.0012 | ||
| AFP(ng/ml) | <0.0011 | ||||
| <10 | 57 (28.9%) | 35 (11.2%) | Ref | ||
| 10–400 | 71 (36%) | 75 (24.1%) | 1.72 (1.01–2.93,P = 0.045) | 1.62 (0.94–2.80,P value = 0.083) | |
| >400 | 69 (35%) | 201 (64.6%) | 4.74 (2.87–7.84,p=<0.001) | 4.19 (2.51–7.03,P value=<0.001) | |
| AFP(ng/ml) | <0.0011 | ||||
| <400 | 128 (65%) | 110 (35.4%) | Ref | ||
| >400 | 69 (35%) | 201 (64.6%) | 3.39 (2.33–4.93) | 4.19 (2.51–7.03,P value=<0.001) | |
| MTD (cm) | <0.0011 | ||||
| ≤5 | 58 (29.4%) | 30 (9.6%) | Ref | ||
| >5 | 139 (70.6%) | 281 (90.4%) | 3.91 (2.40–6.35) | 3.35 (2.02–5.55,P value=<0.001) | |
All values: Mean ± Standard Deviation as continuous; Frequencies and percentage (%) as categorical.
1. Chi-square test 2. Mann–Whitney U test.
MTD (Maximum tumor diameter); AFP (Alfa-fetoprotein); HBHC (Hepatitis B and hepatitis C); NBNC (Nonhepatitis B and nonhepatitis C).