Table 6.
Univariate and Multivariable Logistic Regression Analysis of the Association of AFP Levels With Presence and Absence of ExtraHepatic Disease at Presentation.
| Variable | Extrahepatic metastasis |
P value | OR (95% CI) (Univariate) | OR (95% CI, P value) (multivariate) | ||
|---|---|---|---|---|---|---|
| Absent n = 399 | Present n = 109 | |||||
| Gender | 0.5731 | |||||
| Male | 347 (87%) | 97 (89%) | 1.21 (0.62–2.36) | NA | ||
| Female | 52 (13%) | 12 (11%) | Ref | |||
| Age | 0.0031 | |||||
| ≤40 | 49 (12.3%) | 26 (23.8%) | 2.24 (1.31–3.81) | 1.87 (1.09–3.22,P value = 0.023) | ||
| >40 | 350 (87.7%) | 83 (76.2%) | Ref | |||
| Etiology | 0.2781 | NA | ||||
| HBHC | 237 (59.4%) | 71 (65.1%) | 1.28 (0.82–1.99) | |||
| NBNC | 162 (40.6%) | 38 (34.9%) | Ref | |||
|
AFP (ng/ml) (mean ± SD) |
55420.64 ± 203280.01 |
116718.39 + 295452.47 |
0.0012 | |||
| AFP (ng/ml) | 0.0411 | |||||
| <10 | 79 (19.8%) | 13 (11.9%) | Ref | |||
| 10–400 | 119 (29.8%) | 27 (24.8%) | 1.38 (0.67–2.83, P = 0.382) | 1.26 (0.60–2.64,P = 0.536) | ||
| >400 | 201 (50.4%) | 69 (63.3%) | 2.09 (1.09–3.98, P = 0.026) | 1.69 (0.87–3.29,P = 0.119) | ||
| AFP (ng/ml) | 0.171 | |||||
| ≤400 | 198 (49.6%) | 40 (36.7%) | Ref | |||
| >400 | 201 (50.4%) | 69 (63.3%) | 1.69 (1.09–2.63) | |||
| MTD (cm) | <0.0011 | |||||
| ≤5 | 84 (21.1%) | 4 (3.7%) | Ref | |||
| >5 | 315 (78.9%) | 105 (96.3%) | 7.00 (2.51–19.55) | 5.95 (2.11–16.74,P value = 0.001) | ||
All values: Mean ± Standard Deviation as continuous; Frequencies and percentage (%) as categorical.
1. Chi-square test 2. Mann–Whitney U test.
MTD (Maximum tumor diameter); AFP (Alfa-fetoprotein); HBHC (Hepatitis B and hepatitis C); NBNC (Nonhepatitis B and nonhepatitis C).