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. 2021 Dec 20;16(11):2214–2234. doi: 10.1002/1878-0261.13152

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© 2021 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fig. 1 — Chi3L1 plays an important role in human lung cancer. (A) Serum and tissue levels and receiver operating characteristic (ROC) curve of Chi3L1 in lung cancer patients and its controls. n = 20 for the control group; n = 46 for the patients group. ***P < 0.001 (unpaired two‐tailed t‐test). (B) Representative immunohistochemical images of lung cancer patients. Scale bar, 200 μm. Immunohistochemical staining were repeated from three independent experiments. (C) Chi3L1 expression in lung cancer patients was analyzed by Western blot. n = 5 per group. (D) The effects of Chi3L1 on the overall survival of lung cancer patients, using Kaplan–Meier plotter analysis. (E) Genetic alteration of Chi3L1 in lung cancer patients using cBioPortal.