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. 2022 May 10;53:102331. doi: 10.1016/j.redox.2022.102331

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 8 — Pharmacological inhibition of CBS causes the regression of established tumors in tumor-bearing mouse models. A) Effect of CBS inhibitor (AOAA) in tumor growth rate of NCM356 cell line overexpressing CBS xenografts. Data are shown as mean ± SEM of n = 10 animals per group; ∗p < 0.05 shows significant difference between tumor size between the indicated two time points. The figure was redrawn from data presented in Ref. [48]. B) Effect of CBS inhibitor (YD0171) in tumor growth rate of HCT116 xenografts. Data are shown as mean ± SEM of n = 8 animals per group; ∗p < 0.05 shows significant difference between tumor size between the indicated two time points. The figure was redrawn from data presented in Ref. [155]. C) Effect of CBS inhibitor (AOAA) in tumor growth rate of A549 xenografts. Data are shown as mean ± SEM of n = 5 animals per group; ∗p < 0.05 shows significant difference between tumor size between the indicated two time points. The figure was redrawn from data presented in Ref. [69].