Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Dose reduction effectively lowers osimertinib trough levels. (a) Distribution of osimertinib trough levels in a simulation cohort consisting of 1000 patients. The proposed toxic limit is visualized as a black vertical line (259 ng/mL). (b) Simulated distribution if the proposed 50% dose-reduction is applied for patients who were above the toxic limit in part (a).
