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. Author manuscript; available in PMC: 2022 Jun 6.
Published in final edited form as: Cell Host Microbe. 2020 Jan 8;27(1):8–10. doi: 10.1016/j.chom.2019.12.008

Figure 1. HCMV miRNAs maintain a balance between TGF-β activation and suppression.

Figure 1.

On the left (green), HCMV miR-US5–2 downregulates NAB1, thereby alleviating the NAB1-induced inhibition of TGF-β expression. This leads to an increase in TGF-β secretion and the subsequent myelosuppression of neighboring uninfected cells. On the right (red), HCMV miR-UL22A-3p and −5p downregulate SMAD3 and, as a result, make infected cells unresponsive to TGF-β, which supports the maintenance of latency.