Table 2. . Schedule of study events.

Description	Study visit
Review and sign informed consent	X
Screening demographics	X
Review inclusion and exclusion criteria by disease state	X
Medical history	X
Social history	X
Family history	X
Medication review	X
General physical examination	X
General neurologic examination	X
MDS-UPDRS	X
Hoehn and Yahr	X
European Quality of Life 5D and VAS	X
Parkinson's Disease Questionnaire 39	X
Orthostatic Hypotension Questionnaire	X
Montreal Cognitive Assessment	X
REM Sleep Behavior Disorder Questionnaire	X
Skin biopsies (three locations: distal leg, thigh, neck)	X

The schedule events will occur during a single comprehensive study visit, although testing may be completed over more than 1 day for patient convenience.

MDS-UPDRS: Movement Disorder Society – Sponsored Revision of the Unified Parkinson's Disease Rating Scale; VAS: Visual analogue scale.