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. 2022 May 19;10:912178. doi: 10.3389/fbioe.2022.912178

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Copyright © 2022 Wen, Li, Lin, Li, Song and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AgNPs worsen liver inflammation in mice with NAFLD induced by HFD. The expression of hepatic proinflammatory genes including Tnf-α (A), Il-6 (B), and Il-1β (C) in ND-fed mice and HFD-fed mice treated with AgNPs. Gene expression was normalized to Gapdh. The contents of proinflammatory cytokines including TNF-α (D), IL-6 (E), and IL-1β (F) in the liver of ND-fed mice and HFD-fed mice treated with AgNPs were measured by ELISA. ^* p < 0.05 vs. ND-fed group; ^# p < 0.05 vs. HFD-treated group.