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. 2022 May 19;10:912178. doi: 10.3389/fbioe.2022.912178

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Copyright © 2022 Wen, Li, Lin, Li, Song and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schema of the possible mechanisms of intravenously injected AgNPs on NAFLD development and progression. The potential mechanism of AgNP-induced hepatotoxicity in NAFLD mice is associated with hyperactivation of SREBP-1c-mediated de novo lipogenesis and liver inflammation. Additionally, significantly higher oxidative damage and lower global DNA methylation and DNA hydroxymethylation were observed in HFD-fed mice treated with AgNPs compared with NAFLD group. This study suggests that AgNP treatment exacerbated HFD-induced hepatic steatosis, liver inflammation, oxidative stress, and epigenetic changes in mice, which is relevant to the risk of AgNP exposure on NAFLD development and progression.