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. 2022 May 16;13:877898. doi: 10.3389/fphar.2022.877898

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Copyright © 2022 Liu, Huang, Wan, Lu, Zhou, Li, Yu, Chou, Zhang, Zhang, Qiang, Zhang and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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UA improved cognitive dysfunction induced by epilepsy. (A) Architectural diagram of IntelliCage and experimental program settings. Cage was not drawn to scale. (B) The number of different items of positional learning stage and (C) positional reversal learning stage. Number of visits (D), nosepokes (E), and licks (F) in positional learning from d 1 to d 7. Number of visits (G), nosepokes (H), and licks (I) in positional reversal learning from d 1 to d 7. (J) Open-field test of rats with developed SE induced by pilocarpine at 5 weeks. (K) Novel object recognition test of rats with developed SE induced by pilocarpine at 5 weeks. (n = 6, all values were expressed as means ±SD, ^∗∗∗ p < 0.001, ^∗∗ p < 0.01, ^∗ p < 0.05 vs. SE, one-way ANOVA, two-way ANOVA, or paired t-test).