Table 1.
Demographics and clinical profile at diagnosis of pulmonary hypertension for World Symposium on Pulmonary Hypertension group-1 and -3 patients with and without catheterization at pulmonary hypertension diagnosis
| Status at Pulmonary Hypertension Diagnosis | WSPH Groups 1 and 3 (N = 1,383) | Patients with Baseline Catheterization at Diagnosis |
No Catheterization: at Diagnosis (n = 710) | P Value† | |||
|---|---|---|---|---|---|---|---|
| Overall (n = 671) | WSPH Group 1 (n = 454) | WSPH Group 3 (n = 217) | P Value* | ||||
| Age at pulmonary hypertension diagnosis, yr | n = 1,383 | n = 671 | n = 454 | n = 217 | — | n = 710 | — |
| Median (IQR) | 0.46 (0.08–3.20) | 1.43 (0.36–6.58) | 3.10 (0.61–8.21) | 0.44 (0.21–1.65) | <0.001 | 0.24 (0.01–0.61) | <0.001 |
| Infant (age < 12 mo) | n = 1,383 | n = 671 | n = 454 | n = 217 | <0.001 | n = 710 | <0.001 |
| 878 (63.5) | 302 (45.0) | 151 (33.3) | 151 (69.6) | — | 576 (81.1) | ||
| Preterm (<37 wk) | n = 1,221 | n = 556 | n = 350 | n = 206 | <0.001 | n = 664 | <0.001 |
| 585 (47.9) | 236 (42.4) | 98 (28.0) | 138 (67.0) | — | 349 (52.6) | ||
| Sex | n = 1,383 | n = 671 | n = 454 | n = 217 | 0.004 | — | 0.024 |
| Male | 709 (51.3) | 323 (48.1) | 201 (44.3) | 122 (56.2) | — | 385 (54.2) | — |
| Female | 674 (48.7) | 348 (51.9) | 253 (55.7) | 95 (43.8) | — | 325 (45.8) | — |
| Race | — | — | — | — | 0.017 | — | <0.001 |
| White | 844 (61.0) | 401 (59.8) | 283 (62.3) | 118 (54.4) | — | 441 (62.1) | — |
| Black | 171 (12.4) | 79 (11.8) | 42 (9.3) | 37 (17.1) | — | 92 (13.0) | — |
| Asian | 129 (9.3) | 87 (13.0) | 62 (13.7) | 25 (11.5) | — | 42 (5.9) | — |
| Other/unknown | 239 (17.3) | 104 (15.5) | 67 (14.8) | 37 (17.1) | — | 135 (19.0) | — |
| Hispanic | — | — | — | — | 0.236 | — | 0.119 |
| Yes | 223 (16.1) | 119 (17.7) | 86 (18.9) | 33 (15.2) | — | 104 (14.6) | — |
| No/unknown | 1,160 (83.9) | 552 (82.3) | 368 (81.1) | 184 (84.8) | — | 606 (85.4) | — |
| On supplemental oxygen (at time of catheterization) | n = 1,209 | n = 587 | n = 399 | n = 188 | <0.001 | n = 620 | 0.050 |
| 625 (51.7) | 286 (48.7) | 165 (41.4) | 121 (64.4) | — | 337 (54.4) | — | |
| On any pulmonary hypertension medications | n = 1,366 | n = 671 | n = 454 | n = 217 | 0.893 | n = 693 | <0.001 |
| 727 (53.2) | 415 (61.8) | 280 (61.7) | 135 (62.2) | — | 311 (44.9) | — | |
| Pediatric Functional Class | n = 741 | n = 365 | n = 231 | n = 134 | 0.002 | n = 374 | <0.001 |
| I | 94 (12.7) | 36 (9.9) | 28 (12.1) | 8 (6.0) | — | 58 (15.5) | — |
| II | 212 (28.6) | 131 (35.9) | 91 (39.4) | 40 (29.9) | — | 81 (21.7) | — |
| III A | 143 (19.3) | 90 (24.7) | 60 (26.0) | 30 (22.4) | — | 53 (14.2) | — |
| III B | 61 (8.2) | 36 (9.9) | 19 (8.2) | 17 (12.7) | — | 24 (6.4) | — |
| IV | 231 (31.2) | 72 (19.7) | 33 (14.3) | 39 (29.1) | — | 158 (42.2) | — |
| WHO Functional Class | n = 465 | n = 284 | n = 211 | n = 73 | 0.369 | n = 180 | <0.001 |
| I | 97 (20.9) | 36 (12.7) | 26 (12.3) | 10 (13.7) | — | 61 (33.9) | — |
| II | 187 (40.2) | 122 (43.0) | 97 (46.0) | 25 (34.2) | — | 65 (36.1) | — |
| III | 129 (27.7) | 95 (33.5) | 66 (31.3) | 29 (39.7) | — | 34 (18.9) | — |
| IV | 52 (11.2) | 31 (10.9) | 22 (10.4) | 9 (12.3) | — | 20 (11.1) | — |
| Combined Functional Class | n = 1,002 | n = 515 | n = 354 | n = 161 | <0.001 | n = 487 | <0.001 |
| I | 169 (16.9) | 64 (12.4) | 49 (13.8) | 15 (9.3) | — | 105 (21.6) | — |
| II | 323 (32.2) | 198 (38.4) | 147 (41.5) | 51 (31.7) | — | 125 (25.7) | — |
| III | 263 (26.2) | 172 (33.4) | 117 (33.1) | 55 (34.2) | — | 91 (18.7) | — |
| IV | 247 (24.7) | 81 (15.7) | 41 (11.6) | 40 (24.8) | — | 166 (34.1) | — |
Definition of abbreviations: IQR = interquartile range; WHO = World Health Organization; WSPH = World Symposium on Pulmonary Hypertension.
Data are shown as n (%) unless otherwise specified.
*
P value compares WSPH group 1 with group 3 patients who underwent catheterization at diagnosis and had baseline condition data.
†
P value compares group 1 and 3 patients with baseline catheterization (n = 671) with patients who did not undergo catheterization at pulmonary hypertension diagnosis (n = 710).