Table 6.
Acute vasodilator testing responsiveness on the basis of catheterization at pulmonary hypertension diagnosis
| Measurement | Overall (N = 485) | WSPH Group 1 (n = 333) | WSPH Group 3 (n = 152) | P Value |
|---|---|---|---|---|
| n paired PAPm | 428 | 298 | 130 | — |
| Baseline PAPm, mm Hg | 45.4 ± 19.9 | 49.2 ± 20.6 | 36.6 ± 14.9 | <0.001 |
| Baseline PAPm ⩽ 40 mm Hg | 193 (45.1) | 105 (35.2) | 88 (67.7) | <0.001 |
| Maximal PAPm, mm Hg | 39.2 ± 19.0 | 43.2 ± 20.2 | 29.9 ± 11.9 | <0.001 |
| Maximal PAPm ⩽ 40 mm Hg | 258 (60.3) | 146 (49.0) | 112 (86.2) | <0.001 |
| Drop in PAPm ⩾ 10 mm Hg from baseline | 108 (25.2) | 76 (25.5) | 32 (24.6) | 0.904 |
| Drop in PAPm ⩾ 20% from baseline | 130 (30.4) | 85 (28.5) | 45 (34.6) | 0.211 |
| n paired cardiac index | 361 | 252 | 109 | — |
| Baseline cardiac index, L/min/m2 | 3.60 ± 1.31 | 3.54 ± 1.41 | 3.74 ± 1.02 | 0.145 |
| Median (IQR) | 3.49 (2.75–4.20) | 3.38 (2.60–4.20) | 3.60 (3.10–4.20) | 0.020 |
| Maximal cardiac index, L/min/m2 | 3.68 ± 1.48 | 3.58 ± 1.48 | 3.89 ± 1.45 | 0.064 |
| Median (IQR) | 3.43 (2.80–4.31) | 3.20 (2.63–4.30) | 3.68 (3.19–4.45) | 0.006 |
| Increase or no change in cardiac index | 189 (52.4) | 123 (48.8) | 66 (60.6) | 0.051 |
| n paired PVR/SVR ratio | 265 | 187 | 78 | — |
| PVR/SVR ratio at baseline, median (IQR) | 0.63 (0.40–0.94) | 0.71 (0.49–1.07) | 0.44 (0.33–0.66) | <0.001 |
| Maximal PVR/SVR ratio, median (IQR) | 0.43 (0.26–0.69) | 0.51 (0.30–0.79) | 0.31 (0.24–0.42) | <0.001 |
| Decrease or no change in PVR/SVR ratio | 222 (83.8) | 152 (81.3) | 70 (89.7) | 0.102 |
| Sitbon criteria | — | — | — | 0.195 |
| Responsive | 51 (11.8) | 31 (10.3) | 20 (15.0) | — |
| Nonresponsive | 383 (88.2) | 270 (89.7) | 113 (85.0) | — |
| Barst criteria | — | — | — | 0.091 |
| Responsive | 45 (10.7) | 26 (9.0) | 19 (14.6) | — |
| Nonresponsive | 374 (89.3) | 263 (91.0) | 111 (85.4) | — |
| Modified Barst criteria | — | — | — | 0.075 |
| Responsive | 33 (8.0) | 18 (6.3) | 15 (11.9) | — |
| Nonresponsive | 378 (92.0) | 267 (93.7) | 111 (88.1) | — |
Definition of abbreviations: IQR = interquartile range; PAPm = mean pulmonary arterial pressure; PVR = pulmonary vascular resistance; SVR =systemic vascular resistance; WSPH = World Symposium on Pulmonary Hypertension.
Excludes patients with diagnosis baseline pulmonary-to-systemic flow ratio > 1.5. Paired n represents the number of patients with baseline and maximal condition data. Data are shown as mean ± SD or n (%) unless otherwise specified.