Table 7.
Univariate Cox regression models for death/lung transplantation
| All (N = 671) | Death/Transplantation (n = 79) | Event Free (n = 592) | Hazard Ratio (95% CI) | P Value | |
|---|---|---|---|---|---|
| Follow-up time, yr, median (IQR) | 5.1 (2.6–8.7) | 1.7 (0.4–6.5) | 5.4 (3.0–9.1) | — | — |
| Age at catheterization, yr | 4.24 ± 5.06 | 5.21 ± 5.98 | 4.11 ± 4.92 | 1.037 (0.998–1.08) | 0.064 |
| WSPH group | — | — | — | — | 0.833 |
| 1 | 454 (67.7) | 54 (68.4) | 400 (67.6) | 1.05 (0.65–1.69) | — |
| 3 | 217 (32.3) | 25 (31.6) | 192 (32.4) | Reference | — |
| PAPm, mm Hg | 43.6 ± 19.5 (634) | 51.8 ± 22.1 (75) | 42.6 ± 18.9 (559) | 1.12 (1.06–1.18)* | <0.001 |
| PAPm tertile† | — | — | — | — | <0.001 |
| ⩽32 mm Hg | 230 (36.3) | 16 (7.0) | 214 (93.0) | Reference | — |
| >32 to ⩽50 mm Hg | 200 (31.5) | 22 (11.0) | 178 (89.0) | 1.49 (0.78–2.83) | — |
| >50 mm Hg | 204 (32.2) | 37 (18.1) | 167 (81.9) | 2.86 (1.59–5.16) | — |
| T3 vs. T2 | — | — | — | 1.93 (1.13–3.27) | — |
| PVRi, Wood units ⋅ m2 | 10.7 ± 9.8 (570) | 13.2 ± 11.9 (65) | 10.3 ± 9.4 (505) | 1.13 (1.02–1.25)* | 0.015 |
| PVRi tertile | — | — | — | — | 0.342 |
| ⩽5 | 175 (30.7) | 16 (9.1) | 159 (90.9) | Reference | — |
| >5 to ⩽10 | 190 (33.3) | 20 (10.5) | 170 (89.5) | 1.12 (0.58–2.18) | — |
| >10 | 205 (36.0) | 29 (14.1) | 176 (85.9) | 1.53 (0.82–2.82) | — |
| T3 vs. T2 | — | — | — | 1.36 (0.77–2.40) | — |
| PVRi/SVRi | 0.64 ± 0.48 (495) | 0.75 ± 0.51 (57) | 0.63 ± 0.48 (438) | 1.04 (1.002–1.09)‡ | 0.040 |
| PVRi/SVRi tertile | — | — | — | — | 0.014 |
| ⩽0.4 | 185 (37.4) | 16 (8.6) | 169 (91.4) | Reference | — |
| >0.4 to ⩽0.7 | 149 (30.1) | 14 (9.4) | 135 (90.6) | 0.96 (0.47–1.97) | — |
| >0.7 | 161 (32.5) | 27 (16.8) | 134 (83.2) | 2.17 (1.16–4.09) | — |
| T3 vs. T2 | — | — | — | 2.26 (1.18–4.34) | — |
| Cardiac index, L/min/m2 | 3.56 ± 1.29 (541) | 3.36 ± 1.19 (56) | 3.58 ± 1.30 (485) | 0.99 (0.97–1.02)‡ | 0.504 |
| PAPm/SAPm | 0.75 ± 0.31 (467) | 0.86 ± 0.38 (54) | 0.74 ± 0.30 (413) | 1.13 (1.04–1.23)‡ | 0.004 |
| PAPm/SAPm tertile† | — | — | — | — | 0.001 |
| ⩽0.6 | 167 (35.8) | 15 (9.0) | 152 (91.0) | Reference | — |
| >0.6 to ⩽0.9 | 151 (32.3) | 10 (6.6) | 141 (93.4) | 0.75 (0.34–1.67) | — |
| >0.9 | 149 (31.9) | 29 (19.5) | 120 (80.5) | 2.44 (1.30–4.59) | — |
| T3 vs. T2 | — | — | — | 3.26 (1.58–6.72) | — |
Definition of abbreviations: CI = confidence interval; IQR = interquartile range; PAPm = mean pulmonary arterial pressure; PVRi = pulmonary vascular resistance index; SAPm = systemic pulmonary arterial pressure; SVRi = systemic vascular resistance index; T2 = second tertile; T3 = third tertile; WSPH = World Symposium on Pulmonary Hypertension.
Data are shown as mean ± SD, n (%), or mean ± SD (n) unless otherwise specified.
*
Per 5-unit increase.
†
These two parameters were also examined with respect to mortality alone. P = 0.029 for PAPm tertiles and P = 0.009 for PAPm/SAPm tertiles.
‡
Per 0.1-unit increase.