TABLE 2.
Correlation analysis between ACE2 and gene biomarkers of immune cells in BRCA (TIMER)
| Description | Biomarkers | None | Purity | ||
|---|---|---|---|---|---|
| Cor | p‐Value | Cor | p‐Value | ||
| CD8+ T cell | CD8A | 0.0226 | 3.36e‐14 | 0.116 | 2.42e‐04 |
| CD8B | 0.284 | 8.06e‐22 | 0.191 | 1.21e‐09 | |
| T cell (general) | CD3D | 0.265 | 3.54e‐19 | 0.146 | 3.67e‐06 |
| CD3E | 0.264 | 4.62e‐19 | 0.145 | 4.36e‐06 | |
| CD2 | 0.264 | 5.76e‐19 | 0.154 | 1.07e‐06 | |
| B cell | CD19 | 0.273 | 3.26e‐20 | 0.156 | 7.14e‐07 |
| CD79A | 0.283 | 9.33e‐22 | 0.163 | 2.43e‐07 | |
| Monocyte | CD86 | 0.148 | 7.71e‐07 | 0.06 | 5.69e‐02 |
| CD115(CSF1R) | 0.102 | 6.63e‐04 | ‐0.016 | 6.18e‐01 | |
| TAM | CCL2 | 0.293 | 3.09e‐23 | 0.228 | 3.48e‐13 |
| CD68 | 0.093 | 2.04e‐03 | 0.006 | 8.42e‐01 | |
| IL10 | 0.166 | 2.91e‐08 | 0.096 | 2.36e‐03 | |
| M1 Macrophage | INOS (NOS2) | 0.09 | 2.71e‐03 | 0.063 | 4.54e‐02 |
| IRF5 | 0.009 | 7.7e‐01 | ‐0.048 | 1.33e‐01 | |
| COX2(PTGS2) | 0.402 | 6.47e‐44 | 0.331 | 6.61e‐27 | |
| M2 Macrophage | CD163 | 0.173 | 7.7e‐09 | 0.11 | 5.06e‐04 |
| VSIG4 | 0.107 | 3.61e‐04 | 0.032 | 3.14e‐01 | |
| MS4A4A | 0.173 | 8.18e‐09 | 0.086 | 6.42e‐03 | |
| Neutrophils | CD66b (CEACAM8) | 0.069 | 2.17e‐02 | 0.074 | 2.02e‐02 |
| CD11b (ITGAM) | 0.066 | 2.94e‐02 | ‐0.021 | 5.03e‐01 | |
| CCR7 | 0.244 | 2.1e‐16 | 0.128 | 5.26e‐05 | |
| Natural killer cell | KIR2DL1 | 0.165 | 3.47e‐08 | 0.112 | 4.15e‐04 |
| KIR2DL3 | 0.188 | 3.39e‐10 | 0.115 | 2.74e‐04 | |
| KIR2DL4 | 0.273 | 2.83e‐20 | 0.207 | 4.17e‐11 | |
| KIR3DL1 | 0.188 | 3.42e‐10 | 0.114 | 3.34e‐04 | |
| KIR3DL2 | 0.234 | 3.92e‐15 | 0.15 | 2.08e‐06 | |
| KIR3DL3 | 0.125 | 3.08e‐05 | 0.092 | 3.75e‐03 | |
| KIR2DS4 | 0.219 | 2.34e‐13 | 0.151 | 1.79e‐06 | |
| Dendritic cell | HLA‐DPB1 | 0.138 | 4.11e‐06 | ‐0.017 | 5.89e‐01 |
| HLA‐DQB1 | 0.169 | 1.82e‐08 | 0.071 | 2.47e‐02 | |
| HLA‐DRA | 0.19 | 1.99e‐10 | 0.068 | 3.18e‐02 | |
| HLA‐DPA1 | 0.128 | 2.12e‐05 | ‐0.007 | 8.24e‐01 | |
| BDCA‐1(CD1C) | 0.179 | 2.28e‐09 | 0.032 | 3.13e‐01 | |
| BDCA‐4(NRP1) | 0.151 | 4.62e‐07 | 0.078 | 1.37e‐02 | |
| CD11c (ITGAX) | 0.118 | 9.11e‐05 | 0.003 | 9.35e‐01 | |
| Th1 | T‐bet (TBX21) | 0.285 | 5.55e‐22 | 0.185 | 4.10e‐09 |
| STAT4 | 0.303 | 8.14e‐25 | 0.201 | 1.5e‐10 | |
| STAT1 | 0.154 | 296e‐07 | 0.127 | 5.62e‐05 | |
| IFN‐g (IFNG) | 0.275 | 1.33e‐20 | 0.196 | 4.15e‐10 | |
| TNF‐a (TNF) | 0.172 | 9.72e‐09 | 0.123 | 9.83e‐05 | |
| Th2 | GATA3 | ‐0.553 | 4.88e‐89 | ‐0.522 | 1.69e‐70 |
| STAT6 | ‐0.112 | 2e‐04 | ‐0.151 | 1.80e‐06 | |
| STAT5A | 0.149 | 6.68e‐07 | 0.082 | 9.81e‐03 | |
| IL13 | 0.212 | 1.11e‐12 | 0.16 | 3.74e‐07 | |
| Tfh | BCL6 | 0.076 | 1.2e‐02 | 0.027 | 3.96e‐01 |
| IL21 | 0.202 | 1.28e‐11 | 0.15 | 2.06e‐06 | |
| Th17 | STAT3 | 0.036 | 2.37e‐01 | 0.017 | 6.01e‐01 |
| IL17A | 0.194 | 8e‐11 | 0.158 | 5.38e‐07 | |
| Treg | FOXP3 | 0.282 | 1.75e‐21 | 0.187 | 2.64e‐09 |
| CCR8 | 0.173 | 7.24e‐09 | 0.109 | 5.97e‐04 | |
| STAT5B | ‐0.061 | 4.27e‐02 | ‐0.093 | 3.49e‐03 | |
| TGFb (TGFB1) | ‐0.063 | 3.77e‐02 | ‐0.196 | 4.88e‐10 | |
| T cell exhaustion | PD‐1 (PDCD1) | 0.272 | 4.25e‐20 | 0.172 | 5.30e‐08 |
| CTLA4 | 0.326 | 1.4e‐28 | 0.244 | 5.67e‐15 | |
| LAG3 | 0.252 | 2.39e‐17 | 0.201 | 1.65e‐10 | |
| TIM‐3 (HAVCR2) | 0.087 | 3.98e‐03 | 0.002 | 9.39e‐01 | |
| GZMB | 0.356 | 4.06e‐34 | 0.281 | 1.83e‐19 | |