Table 2.

Comparison of AGEs, sRAGE isoforms, and their ratios between healthy controls (CTR) and patients with type 2 diabetes

	CTR (n = 125)	Type 2 diabetes (n = 362)	P-value
sRAGE (pg/mL)	430.6 (275.0–595.9)	667.7 (464.8–929.9)	< 0.001
esRAGE (pg/mL)	242.9 (153.9–362.3)	283.5 (138.0–432.9)	0.312
cRAGE (pg/mL)	149.0 (44.7–267.8)	324.1 (173.7–521.0)	< 0.001
AGEs (µg/ml)	4.41 (2.45–6.23)	11.15 (4.43–21.40)	< 0.001
AGEs/sRAGE	0.009 (0.005–0.018)	0.017 (0.006–0.035)	< 0.001
AGEs/esRAGE	0.016 (0.010–0.026)	0.055 (0.024–0.099)	< 0.001
AGEs/cRAGE	0.030 (0.011–0.103)	0.036 (0.011–0.095)	0.914

Data are median (IQR)

P-values for Mann–Whitney U test. Significant differences are in bold