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. 2022 Jun 6;21:95. doi: 10.1186/s12933-022-01535-3

Table 4.

Age- and HbA1c-adjusted multiple quantile regression model for the evaluation of AGEs and sRAGE isoforms in type 2 diabetes complications

Neuropathy Nephropathy Retinopathy PAD MACE
Variable Coeff. p Coeff. p Coeff. p Coeff. p Coeff. p
sRAGE − 130.7 0.041 2.130 0.976 44.7 0.456 26.4 0.786 − 9.875 0.889
cRAGE − 30.40 0.475 28.49 0.551 85.38 0.034 127.9 0.049 − 81.14 0.087
AGEs 3.187 0.158 − 0.487 0.847 − 5.965 0.005 − 0.863 0.801 − 1.23 0.466
AGEs/sRAGE 0.010 0.008 0.001 0.846 − 0.009 0.016 − 0.005 0.349 − 0.001 0.794
AGEs/esRAGE 0.020 0.038 − 0.001 0.960 − 0.005 0.579 0.007 0.642 − 0.023 0.028
AGEs/cRAGE 0.016 0.090 0.005 0.656 − 0.024 0.006 − 0.013 0.363 0.001 0.912

In bold significant associations

Quantile regression models the relationship between a set of predictor variables (type 2 diabetes complications) and specific quantiles of target variables

Coefficient are displayed for the 0.5 quantile (median)