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. 2022 May 16;12(9):4288–4309. doi: 10.7150/thno.70929

Figure 4.

Figure 4

Grafted astroglia improve locomotive function and electrophysiological transmission after SCI. (A, B) BMS scores from open-field tests for hindlimb locomotion performed weekly after transection (n = 10 per group). Two-way ANOVA followed by Bonferroni's multiple comparisons test. Data are mean ± SD; ***p < 0.001. (C) Schematic of EMG analysis of the right hindlimb TA muscle to test electrophysiological transmission 4 weeks after astroglial transplantation. (D) The hip, knee, ankle, and foot joints of the right hindlimb were marked by small discs. (E) Right hindlimb kinematics and hindlimb end-point trajectory. (F-I) EMGs of sham, vehicle, NPC-Astro, and Olig2PC-Astro mice. (J, K) Mean EMG amplitude (J) and mean EMG interval (K) in sham, vehicle, NPC-Astro, and Olig2PC-Astro mice (n = 5 per group). (L) Schematic of gait analysis performed at 4 weeks post-transplantation. (M) Footprints of sham, vehicle, NPC-Astro, and Olig2PC-Astro mice. (N, O) Mean base of support (N) and stride length (O) in sham, vehicle, NPC-Astro, and Olig2PC-Astro mice (n = 5 per group). For (J, K, N, O): Brown-Forsythe and Welch ANOVA followed by Dunnett's T3 multiple comparisons test. Data are mean ± SD; *p < 0.05, **p < 0.01, ***p < 0.001.