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. 2022 May 13;12(9):4110–4126. doi: 10.7150/thno.71392

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MEndoT downregulated by Wnt4 knockdown. (A-C) qPCR analysis of gene expression in cardiac fibroblasts after Wnt4 shRNA lentivirus transduction, n = 4. (A) Wnt4. (B) Endothelial cell marker genes and angiogenesis-related genes. (C) Fibroblast cell marker genes and pro-fibrotic genes. (D) Capillary tube formation on Matrigel and the quantification, n = 3, Scale bar: 750 µm. (E) Ac-LDL intake and the quantification, n = 5, Scale bar: 200 µm. (All graphs show mean ± S.E.M; *p < 0.05, **p < 0.01, ***p < 0.001, using unpaired t-test, one-way anova and two-way anova, fluorophores is indicated by arrowhead.) Note: Angpt1 (angiopoietin 1), α-SMA (actin alpha 2, smooth muscle, aorta), CD31 (Pecam1, platelet and endothelial cell adhesion molecule 1), Cdh2 (cadherin 2), Cthrc1 (collagen triple helix repeat containing 1), eNOS (nitric oxide synthase 3), IL-34 (interleukin 34), Pdgfd (platelet derived growth factor D), Postn (periostin), Sparc (secreted acidic cysteine rich glycoprotein), TGF-β1 (transforming growth factor beta 1), VECAD (cadherin 5).