Table 2.

Summary of the 16 canonical and non-canonical miRNA-editing events

Editing class	miRNA	Cytoband	Position in mature miRNA	Editing in seed	Base substitution	Adjusted P	# detected individuals	Mean-editing level
A-to-I	miR-589-3p	7p22.1	6	Yes	A → G	5.4 × 10−12	0†	0.046
	miR-6503-3p	11q12.2	7	Yes	A → G	< 1 × 10−300	25	0.36
	miR-411-5p	14q32.31	5	Yes	A → G	1.0 × 10−55	3	0.033
	miR-381-3p	14q32.31	4	Yes	A → G	< 1 × 10−300	21	0.17
	miR-421	Xq13.2	14	No	A → G	5.9 × 10−4	0†	0.0035
	miR-652-5p	Xq23	11	No	A → G	2.1 × 10−11	0†	0.011
	miR-505-5p	Xq27.1	4	Yes	A → G	0.037	0†	0.0032
C-to-U	miR-425-5p	3p21.31	14	No	C → U	< 1 × 10−300	86	0.026
	miR-487b-3p	14q32.31	14	No	C → U	3.4 × 10−5	0†	0.0034
	miR-652-3p	Xq23	11	No	C → U	1.9 × 10−18	1	0.013
Non-canonical	miR-1843	1q25.1	16	No	C → A	2.6 × 10−7	0†	0.012
	miR-30d-5p	8q24.22	9	No	U → C	6.4 × 10−7	0†	0.0052
	miR-379-3p	14q32.31	11	No	G → A	1.6 × 10−7	1	0.017
	miR-324-5p	17p13.1	5	Yes	U → C	7.3 × 10−4	0†	0.0025
	miR-144-5p	17q11.2	15	No	A → C	1.4 × 10−51	3	0.0023
	miR-223-5p	Xq12	14	No	A → C	2.2 × 10−12	1	0.0030

Novel editing sites are highlighted in bold.

Adjusted P, P-values calculated with sRNA-seq reads combined across all individuals and adjusted by the Benjamini–Hochberg method.

# detected individuals, the number of individuals in which a given miRNA-editing event was significantly detected (see Materials and Methods).

^†The editing event was detected only when sRNA-seq reads were combined across all individuals.