Figure 1. Kaplan-Meier survival curve of APP/PS1 mice, WT C57BL/6 mice, and Wistar rats subjected to experimental polymicrobial sepsis triggered by CLP. Control groups subjected to sham surgery were included for comparison. The animals were followed for 10 days and mortality was recorded (APP/PS1, sepsis n=32 vs. control n=16, p = 0.153; C57BL/6 mice, sepsis n=50 vs. control n=50, p < 0.001; Wistar rats, sepsis n=12 vs. control n=10, p = 0.02). The APP/PS1 mice subjected to sepsis had an 87.88% survival rate, WT mice had a survival rate of 56%, and Wistar rats had a survival rate of 58.33%. APP/PS1 = amyloid-β precursor protein/presenilin 1; CLP = cecal ligation and puncture.