Summary of findings 2. Summary of findings table ‐ Supine compared to good‐lung dependent for acute respiratory distress in hospitalised infants and children (ARDs).

Supine compared to good‐lung dependent for acute respiratory distress in hospitalised infants and children (ARDs)
Patient or population: acute respiratory distress in hospitalised infants and children (ARDs) Setting: hospital (paediatric critical care unit) Intervention: supine Comparison: good‐lung dependent
Outcomes	Anticipated absolute effects* (95% CI)		Relative effect (95% CI)	№ of participants (studies)	Certainty of the evidence (GRADE)	Comments
	Risk with good‐lung dependent	Risk with supine
Mortality (respiratory events) ‐ not reported	‐	‐	‐	‐	‐	No studies reported this outcome
Oxygen saturation (SaO2) ‐ not reported	‐	‐	‐	‐	‐	No studies reported this outcome
PaO2 follow‐up: range 15 minutes to 45 minutes	The mean paO2 was 111.92 mmHg	mean 3.44 mmHg higher (23.12 lower to 30 higher)	‐	50 (1 RCT)	⊕⊝⊝⊝ Very lowa,b,c
Blood gases (PaCO2) ‐ not reported	‐	‐	‐	‐	‐	No studies reported this outcome
Lung function (PaO2/FiO2 ratio) ‐ not reported	‐	‐	‐	‐	‐	No studies reported this outcome
Oxygenation index (FiO2% X MPAW/PaO2) ‐ not reported	‐	‐	‐	‐	‐	No studies reported this outcome
Potential adverse outcomes (episodes of apnoea) ‐ not reported	‐	‐	‐	‐	‐	No studies reported this outcome
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval
GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect.
See interactive version of this table: https://gdt.gradepro.org/presentations/#/isof/isof_question_revman_web_423282959442933151.

^a We identified significant issues with the randomisation process as well as concealment of allocation
^b A very wide and imprecise confidence intervals (CI), suggesting possible benefit or harm
^c A very small single study