Summary of findings 4. Summary of findings table ‐ Good‐lung independent compared to good‐lung dependent positioning for acute respiratory distress in hospitalised infants and children.
| Good‐lung independent compared to good‐lung dependent positioning for acute respiratory distress in hospitalised infants and children | ||||||
| Patient or population: acute respiratory distress in hospitalised infants and children Setting: hospital (paediatric critical care unit) Intervention: good‐lung independent Comparison: good‐lung dependent positioning | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
| Risk with good‐lung dependent positioning | Risk with good‐lung independent | |||||
| Mortality (respiratory events) ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | No studies reported this outcome |
| Oxygen saturation (SaO2) ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | No studies reported this outcome |
| PaO 2 (cross‐over trial) follow‐up: range 15 minutes to 45 minutes | The mean paO 2 (cross‐over trial) was 111.92 mmHg | MD 6.22 mmHg higher (21.25 lower to 33.69 higher) | ‐ | 50 (1 RCT) | ⊕⊝⊝⊝ Very lowa,b,c | |
| Blood gases (PaCO2) ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | No studies reported this outcome |
| Lung function (PaO2/FiO2 ratio) ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | No studies reported this outcome |
| Oxygenation index (FiO2% X MPAW/PaO2) ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | No studies reported this outcome |
| Potential adverse outcomes (episodes of apnoea) ‐ not reported | ‐ | ‐ | ‐ | ‐ | ‐ | No studies reported this outcome |
| *The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; MD: mean difference | ||||||
| GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. | ||||||
| See interactive version of this table: https://gdt.gradepro.org/presentations/#/isof/isof_question_revman_web_429747819004596191. | ||||||
a We identified significant issues due to randomisation and poor allocation concealment b Very large confidence intervals suggesting possible benefit or harm c Downgraded due to findings from very small single study