NCT04946812.

Study name	Split‐belt treadmill training to rehabilitate freezing of gait and balance in Parkinson's disease
Methods	RCT
Participants	Target sample size: 28 Inclusion criteria: Idiopathic Parkinson's disease, Hoehn & Yahr Stage 2‐3 when on levodopa, freezing of gait that is resistant to dopaminergic therapy, disease duration 5 to 15 years, stable clinical response to medications or stimulation parameters (if DBS) for at least 3 months, mini‐mental state examination >24/30, able to walk on a motor‐driven treadmill. Exclusion criteria: Severe imbalance that limits walking ability (Hoehn &Yahr score above 3), orthopaedic conditions and other systemic disease affecting walking, cardiac conditions limiting the ability to walk uninterrupted for 1 hour, other neurological disorders, not fluent in English.
Interventions	1. Split‐belt treadmill training, where the velocity of the belt will be reduced on the least affected side by 25%, starting at 20 minutes per session and increasing over 18 sessions conducted across 3 weeks. 2. Tied‐belt treadmill training, starting at 20 minutes per session and increasing over 18 sessions conducted across 3 weeks.
Outcomes	1. Rate of falls 2. Number of fallers 3. Health‐related quality of life (PDQ39) Other outcomes not relevant to this review
Starting date	March 27, 2020
Contact information	Prof Alfonso Fasano Toronto Western Hospital Email: alfonso.fasano@uhn.ca
Notes