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. Author manuscript; available in PMC: 2023 Apr 27.
Published in final edited form as: Sci Transl Med. 2022 Apr 27;14(642):eabn2263. doi: 10.1126/scitranslmed.abn2263

Figure 4. Skin of CLE patients exhibits an abnormal T cell infiltrate at both lesional and non-lesional sites.

Figure 4.

a. UMAP plot of 3,030 T cells colored by disease state. b. UMAP plot of T cells colored by subset. Tcm, central memory T cells; Tem, effector memory T cells; Trm, tissue-resident memory T cells; CD161+ Tm, CD161+ memory T cells; Treg, probable regulatory T cells; Tph/Tfh, T peripheral helper and/or T follicular helper cells; IFN T, interferon T cells; CD8T, CD8+ T cells; NKC, natural killer cells. c. Dot plot of representative marker genes for each T cell subset. Color scale, average marker gene expression. Dot size, percentage of cells expressing marker gene. d. Bar plot of each T cell subset showing the relative contribution of the three disease states. Values are normalized to the total number of T cells for each disease state. e. Dot plot of the top 15 differentially expressed genes (DEGs) downregulated and upregulated in N vs. H Tregs.