Fig. 2.

Functional characterization of Kv7.2 and Kv7.5 channels carrying naturally and nonnaturally occurring variants at position G1. (A) Macroscopic currents from Kv7.2 and Kv7.2 G1S homomeric channels, in response to the indicated voltage protocol. Current scale, 200 pA; time scale, 200 ms. (B) Current densities from the indicated homomeric channels. Asterisks indicate values significantly different (*P < 0.05) from respective controls (Kv7.2 or Kv7.5 channels). (C) Conductance/voltage curves for the indicated channels. Continuous lines are Boltzmann fits of the experimental data.