Skip to main content
. 2022 Apr 4;119(15):e2116887119. doi: 10.1073/pnas.2116887119

Fig. 4.

Fig. 4.

Effect of DrVSP or PIP5K on Kv7.2 and Kv7.2 G1S homomeric channels. (A) Currents recorded in response to the indicated voltage protocol in cells expressing DrVSP and Kv7.2 or Kv7.2 G1S channels. Time scale, 1 s. (B) Time-dependent current decrease in cells coexpressing the indicated channels and DrVSP, expressed as the ratio between the current values recorded at 0 mV immediately after (t2) and before (t1) the Dr-VSP–activating +100 mV depolarizing step. (C) Macroscopic currents recorded in response to the indicated voltage protocol in cells expressing Kv7.2 or Kv7.2 G1S channels in the absence or presence of PIP5K. Current scale, 500 pA; time scale, 200 ms. (D) Current densities at 0 mV from cells expressing Kv7.2 or Kv7.2 G1S channels alone or in combination with PIP5K, as indicated. The asterisk indicates a value significantly different (*P < 0.05) from Kv7.2 currents.