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. Author manuscript; available in PMC: 2022 Jun 6.
Published in final edited form as: J Leukoc Biol. 2021 May 11;109(6):1033–1043. doi: 10.1002/JLB.1HI1120-779R

FIGURE 3. Hierarchical clustering analysis and pairwise correlation matrix of cytokine profiles and age revealed that G-CSF levels are closely associated with IL-1β and MIP-1α levels as well as with aging.

FIGURE 3.

Multiplex cytokines profiles were measured in 123 rhesus macaques aged 2 – 24 years old. (A) Hierarchical clustering analysis was performed on 18 plasma cytokines levels. Sex; red = female and blue = male. (B) A pairwise Spearman correlation matrix was performed for cytokine levels and age. Red indicates positive correlations (r > 0) and blue indicates negative correlations (r < 0). P < 0.05 was considered statistically significant. Scatter plots were shown between G-CSF and IL-1β (C), MIP-1α (D) with the ages of the animals indicated by the color intensity and size of the dots. Spearman nonparametric correlation coefficient (r) and P value were calculated.