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Large-amplitude structure fluctuations of NK1R[2–335] in nanodiscs at 298 K detected by 19F-NMR observation of the bound drug aprepitant. The color code used for the Lorentzian deconvolution is presented the same as in Fig. 1D. A green line represents nanodiscs-associated “free” aprepitant. (A and B) 19F-NMR saturation transfer between the trifluoromethyl groups of aprepitant bound to NK1R[2–335]. Same presentation as in Fig. 2.
