Fig. 1.

Oleic acid binding to the nuclear receptor TLX promotes hippocampal neurogenesis. (A) In the absence of oleic acid, TLX is associated with corepressors; thus, transcription at its target genes is repressed, and neural stem cells are maintained in a quiescent state. (B) When oleic acid is bound to TLX, corepressors are dissociated from TLX; instead, transcriptional coactivators are recruited to promote transcription at TLX target genes, leading to cell cycle progression and neurogenesis. The figure was created with BioRender.com.