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Schematic models of FLT3-ITD–regulated miR-126 and miR-155 expression through feedback and feed-forward loops network. (A and B) Examples of feedback (A) and feed-forward (B) loops. (C) Top, a feedback loop of miR-126 and SPRED1. Bottom, a feedback loop of miR-155 and DDX3X. (D) Feed-forward loop of FLT3-ITD–regulated miR-126 expression through miR-155/SHIP1/AKT axis. Node 1, FLT3-ITD/AKT; node 2, SPRED1/miR-126; node 3, DDX3X/miR-155. GTP, guanosine-5'-triphosphate.
