Figure 2.

The behaviors of MBs during LIFU application. (A) The different properties of an intermittent pulsed LIFU. (B) How MBs change size (shown below the wave) during the two phases of the ultrasound (i.e., compression and rarefaction). (C) How do MBs increase in size (shown below the wave) while pressure is increased eventually resulting in violent collapse? (D) How do these changes affect the permeability of the cerebral vasculature in glioblastoma tissues? The black (short arrows) arrows represent oscillations on the left, expansions and contractions in the middle, and eventually collapse on the right of the illustration. The red (full) arrows represent the pressure exerted by the MBs on the ECs of the cerebral blood vessels.