Table 1: Parameters identified as significant from sensitivity analysis.

For each analysis, parameters shown here have a PRCC absolute value of ρ > 0.1 and p-value<0.05. Parameters listed as associated with clinical outcomes are the result of our ‘all-in-one’ sensitivity analysis. Clinical-scale classifications were assigned a value of 0 (active TB case), 1 (LTBI) or 2 (TB eliminator) to calculate the PRCC value for each parameter. Parameters listed as associated with granuloma CFU were the result of our intra-compartment analysis. These parameters were significantly correlated with granuloma CFU at day 200. PRCC values are listed in Supplementary Material.

Parameters associated with clinical-scale outcomes	Description of parameters ‘All-in-One’ sensitivity analysis
LN k13	Precursor CD8+ T cell proliferation within the lymph node
LN k14	CD8+ T cell differentiation to CD8+ effector T cell in lymph node
LN k4	Precursor CD4+ T cell proliferation within the lymph node
LN k5	CD4+ T cell differentiation to CD4+ effector T cell in lymph node
Parameters associated with granuloma-scale CFU outcomes	Description of parameters Intra-compartment sensitivity analysis
k2	Resting macrophage infection rate
c9	Likelihood of resting macrophages to phagocytize bacteria
N	Carrying capacity of intracellular bacteria within macrophages
k17	Max rate of infected macrophage death from intracellular bacteria
k18	Extracellular bacterial killing by resting macrophages
k14a	Fas:FasL induced apoptosis of MI
alphall	IL-4 production from primed T cells